THE PKRRATING DIARIES

The activated enzyme then phosphorylates its significant substrate, the translational initiation factor eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to the conserved family of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in response to distinct stimuli12, triggering the built-in press